{"id":2572,"date":"2023-07-20T12:52:42","date_gmt":"2023-07-20T12:52:42","guid":{"rendered":"https:\/\/www.floridarehab.com\/?page_id=2572"},"modified":"2025-02-07T12:22:49","modified_gmt":"2025-02-07T12:22:49","slug":"can-cocaine-use-cause-depression","status":"publish","type":"blog","link":"https:\/\/www.floridarehab.com\/drugs\/cocaine\/can-cocaine-use-cause-depression\/","title":{"rendered":"Can Cocaine Use Cause Depression?"},"content":{"rendered":"\n<p class=\"has-text-align-center has-large-font-size wp-block-paragraph\"><strong>Doctors are still debating the reasons behind why depression often occurs in people who use cocaine.<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><a href=\"\/drugs\/cocaine\/\">Cocaine<\/a>&nbsp;is&nbsp;<strong>strongly linked<\/strong>&nbsp;to depression. One study shows that&nbsp;<a href=\"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&amp;pid=S2237-60892017000100034&amp;lng=en&amp;nrm=iso&amp;tlng=en\" target=\"_blank\" rel=\"noreferrer noopener\">nearly half<\/a>&nbsp;of people who struggle with cocaine use and&nbsp;<a href=\"\/treatment\/dual-diagnosis\/\">mental health issues<\/a>&nbsp;are depressed. Doctors have debated whether the drug itself causes depression or if people with depression are more likely to use it.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Other doctors have pointed out that a cocaine use disorder itself can cause depression, due to the stress of living with an addiction. Although the debate is ongoing, evidence shows that people who struggle with cocaine are more likely to be depressed.<\/p>\n\n\n\n<figure class=\"wp-block-embed is-type-video is-provider-youtube wp-block-embed-youtube wp-embed-aspect-16-9 wp-has-aspect-ratio\"><div class=\"wp-block-embed__wrapper\">\n<iframe title=\"The Relationship Between Depression &amp; Drug Misuse #mentalhealth #drugaddition\" width=\"800\" height=\"450\" src=\"https:\/\/www.youtube.com\/embed\/gE1tNlzyQ0E?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\" allowfullscreen><\/iframe>\n<\/div><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\">Depressive Effects of Cocaine<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Although cocaine is a stimulant that can cause euphoria, the drug is also&nbsp;<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC2570759\/\" target=\"_blank\" rel=\"noreferrer noopener\">linked<\/a>&nbsp;to depressive symptoms. One&nbsp;<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4252393\/\" target=\"_blank\" rel=\"noreferrer noopener\">study<\/a>&nbsp;showed that people who struggled with cocaine use were more likely to be depressed after using it, as opposed to being depressed before use.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Doctors are not completely sure why this happens. One&nbsp;<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC2570759\/\" target=\"_blank\" rel=\"noreferrer noopener\">explanation<\/a>&nbsp;may be that cocaine overstimulates the brain\u2019s pleasure center, leading to eventual depression. Doctors have also noticed that certain areas in the brain are involved in both&nbsp;<a href=\"\/drugs\/cocaine\/addiction\/\">cocaine addiction<\/a>&nbsp;and depression. These&nbsp;<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26059306\" target=\"_blank\" rel=\"noreferrer noopener\">include<\/a>&nbsp;the limbic system and the nucleus accumbens.<\/p>\n\n\n\n\n\n<h3 class=\"wp-block-heading\">Effect on Neurotransmitters<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Cocaine causes euphoria by creating an excess of dopamine, the brain\u2019s \u201cfeel-good\u201d chemical. Cocaine also increases levels of the brain chemical serotonin, which is involved in depression. Doctors have&nbsp;<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/27667004\" target=\"_blank\" rel=\"noreferrer noopener\">found<\/a>&nbsp;that chronic cocaine use may prevent cells in the brain from using dopamine as well as they should. Doctors think this may&nbsp;<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/27667004\" target=\"_blank\" rel=\"noreferrer noopener\">cause<\/a>&nbsp;some symptoms of depression, such as the loss of pleasure.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">These changes to how the brain uses dopamine may be&nbsp;<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4961771\/\" target=\"_blank\" rel=\"noreferrer noopener\">permanent<\/a>. However, researchers are&nbsp;<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26059306\" target=\"_blank\" rel=\"noreferrer noopener\">studying<\/a>&nbsp;chemicals in the brain to find new therapies that treat both cocaine addiction and depression.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Cocaine Comedown<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Cocaine causes a rush of feel-good brain chemicals,&nbsp;<a href=\"https:\/\/methoide.fcm.arizona.edu\/infocenter\/index.cfm?stid=170\" target=\"_blank\" rel=\"noreferrer noopener\">including<\/a>:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Norepinephrine:<\/strong>&nbsp;causes energy<\/li>\n\n\n\n<li><strong>Dopamine:<\/strong>&nbsp;causes euphoria<\/li>\n\n\n\n<li><strong>Serotonin:<\/strong>&nbsp;causes confidence<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">During chronic cocaine use, the brain adapts to having extra amounts of these chemicals. If cocaine use suddenly stops and the increased chemical levels are no longer available, withdrawal symptoms begin. These symptoms often include depression.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Depression During Cocaine Withdrawal<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Depression is a common side effect of&nbsp;<a href=\"https:\/\/www.floridarehab.com\/drugs\/cocaine\/withdrawal-detox\/\">cocaine withdrawal<\/a>&nbsp;and often lasts for&nbsp;<a href=\"https:\/\/www.dea.gov\/factsheets\/cocaine\" target=\"_blank\" rel=\"noreferrer noopener\">several days<\/a>. In severe cases, however, it can last for&nbsp;<a href=\"https:\/\/medlineplus.gov\/ency\/article\/000947.htm\" target=\"_blank\" rel=\"noreferrer noopener\">months<\/a>. It is especially common in people who have more extreme&nbsp;<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC2570759\/\" target=\"_blank\" rel=\"noreferrer noopener\">highs<\/a>&nbsp;on cocaine, and it may also be more common in&nbsp;<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC2570759\/\" target=\"_blank\" rel=\"noreferrer noopener\">women<\/a>&nbsp;than men. In addition to depression, other symptoms like exhaustion and sleep often occur.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Cocaine Dependence<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Some people with depression may begin to take cocaine to self-treat their symptoms. If they stop taking cocaine, the symptoms may&nbsp;<a href=\"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&amp;pid=S2237-60892017000100034&amp;lng=en&amp;nrm=iso&amp;tlng=en\" target=\"_blank\" rel=\"noreferrer noopener\">recur<\/a>. Because of changes to brain chemistry from cocaine, the recurring depression symptoms may also be worse than before.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Dual Diagnosis Treatment<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">In&nbsp;<a href=\"\/treatment\/dual-diagnosis\/\">dual diagnosis<\/a>&nbsp;treatment, substance use disorders and mental health issues are treated at the same time. Treating both cocaine addiction and depression simultaneously is important. People with depression who are in treatment for cocaine use tend to have&nbsp;<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4252393\/\" target=\"_blank\" rel=\"noreferrer noopener\">more cravings<\/a>&nbsp;than those who are not depressed. Further, they have a&nbsp;<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4252393\/\" target=\"_blank\" rel=\"noreferrer noopener\">higher risk<\/a>&nbsp;of relapse. Because of this, addressing depression as well as cocaine use is important to rehab success. Fortunately, therapy has been shown to&nbsp;<a href=\"https:\/\/www.drugabuse.gov\/publications\/research-reports\/cocaine\/what-treatments-are-effective-cocaine-abusers\" target=\"_blank\" rel=\"noreferrer noopener\">help<\/a>&nbsp;the depressive symptoms of people who struggle with cocaine.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>If you struggle with cocaine use and depression, The Recovery Village Palm Beach at Baptist Health is here to help.&nbsp;<a href=\"\/contact-us\/\">Contact us<\/a>&nbsp;today to learn more about treatment programs that can help you recover from a substance use disorder and co-occurring mental health condition.<\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Doctors are still debating the reasons behind why depression often occurs in people who use cocaine. Cocaine&nbsp;is&nbsp;strongly linked&nbsp;to depression. One study shows that&nbsp;nearly half&nbsp;of people who struggle with cocaine use and&nbsp;mental health issues&nbsp;are depressed. Doctors have debated whether the drug itself causes depression or if people with depression are more likely to use it. Other [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":11578,"parent":2530,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false},"categories":[103],"tags":[],"class_list":["post-2572","blog","type-blog","status-publish","has-post-thumbnail","hentry","category-cocaine"],"acf":{"written_by":287,"enable_medically_and_up":["Yes"],"medically_reviewed_by":289,"medically_reviewed_content":"This article was reviewed by a medical professional to guarantee the delivery of accurate and up-to- date information. <a href=\"\/research\/\">View our research policy.<\/a>","up_to_date":"<i>Last Updated<\/i> - <b>8\/15\/2022<\/b>","page_first_published_date":"20200815","page_last_edit_date":"20200815","highlighted_description":"If you or a loved one is struggling with addiction, help is available. Speak with a Recovery Advocate by calling <a href=\"tel:8886480738\" > (561) 340-7269<\/a> now.","key_takeaways":"","source":{"source_label":"View Sources","source_content":"<div id=\"KbrcAfL5\" class=\"accordion-container\">\r\n<div class=\"accordion-item-container\">\r\n\r\nUnited States Drug Enforcement Administration. \u201c<a href=\"https:\/\/www.dea.gov\/factsheets\/cocaine\" target=\"_blank\" rel=\"noopener\">Cocaine<\/a>.\u201d (n.d.). Accessed October 6, 2019.\r\n\r\nArango-Lievano, Margarita; Kaplitt, Michael. \u201c<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26059306\" target=\"_blank\" rel=\"noopener\">Depression and Addiction Comorbidity: Towards a Common Molecular Target?<\/a>\u201d Medicine Sciences, May 2015. Accessed October 6, 2019.\r\n\r\nConner, Kenneth; et al \u201c<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC2570759\/\" target=\"_blank\" rel=\"noopener\">Meta-analysis of Depression and Substance Use and Impairment Among Cocaine Users<\/a>.\u201d Drug and Alcohol Dependence, November 1, 2008. Accessed October 6, 2019.\r\n\r\nLister, Jamey; et al. \u201c<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4252393\/\" target=\"_blank\" rel=\"noopener\">Causal Pathways Between Impulsiveness, Cocaine Use Consequences, and Depression<\/a>.\u201d Addictive Behaviors, February 2015. Accessed October 6, 2019.\r\n\r\nPaiva, Camila; et al. \u201c<a href=\"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&amp;pid=S2237-60892017000100034&amp;lng=en&amp;nrm=iso&amp;tlng=en\" target=\"_blank\" rel=\"noopener\">Depression, Anxiety, Hopelessness and Quality of Life in Users of Cocaine\/crack in Outpatient Treatment<\/a>.\u201d Trends in Psychiatry and Psychotherapy, January\/March 2017. Accessed October 6, 2019.\r\n\r\nCreed, Meaghan; et al. \u201c<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/27667004\" target=\"_blank\" rel=\"noopener\">Convergence of Reinforcing and Anhedonic Cocaine Effects in the Ventral Pallidum<\/a>.\u201d Neuron, October 2016. Accessed October 6, 2019.\r\n\r\nSiciliano, Cody; et al. \u201c<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4961771\/\" target=\"_blank\" rel=\"noopener\">Cocaine Self-Administration Produces Long-Lasting Alterations in Dopamine Transporter Responses to Cocaine<\/a>.\u201d Journal of Neuroscience, July 27, 2016. Accessed October 6, 2019.\r\n\r\nNational Institute on Drug Abuse. \u201c<a href=\"https:\/\/www.drugabuse.gov\/publications\/research-reports\/cocaine\/what-treatments-are-effective-cocaine-abusers\" target=\"_blank\" rel=\"noopener\">How is Cocaine Addiction Treated?<\/a>\u201d May 2016. Accessed October 6, 2019.\r\n\r\nU.S. National Library of Medicine. \u201c<a href=\"https:\/\/medlineplus.gov\/ency\/article\/000947.htm\" target=\"_blank\" rel=\"noopener\">Cocaine Withdrawal<\/a>.\u201d September 11, 2019. Accessed October 6, 2019.\r\n\r\nThe University of Arizona MethOIDE. \u201c<a href=\"https:\/\/methoide.fcm.arizona.edu\/infocenter\/index.cfm?stid=170\" target=\"_blank\" rel=\"noopener\">Cocaine Overview: Pharmacology<\/a>.\u201d (n.d.). Accessed October 6, 2019.\r\n\r\n<\/div>\r\n<\/div>"},"staff_member_heading":"Authorship","staff_member":[{"staff_member_title":"Editor","select_staff_member":287},{"staff_member_title":"Medical Reviewer","select_staff_member":289}],"insurance_label":""},"_links":{"self":[{"href":"https:\/\/www.floridarehab.com\/wp-json\/wp\/v2\/blog\/2572","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.floridarehab.com\/wp-json\/wp\/v2\/blog"}],"about":[{"href":"https:\/\/www.floridarehab.com\/wp-json\/wp\/v2\/types\/blog"}],"author":[{"embeddable":true,"href":"https:\/\/www.floridarehab.com\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/www.floridarehab.com\/wp-json\/wp\/v2\/comments?post=2572"}],"version-history":[{"count":0,"href":"https:\/\/www.floridarehab.com\/wp-json\/wp\/v2\/blog\/2572\/revisions"}],"up":[{"embeddable":true,"href":"https:\/\/www.floridarehab.com\/wp-json\/wp\/v2\/blog\/2530"}],"acf:post":[{"embeddable":true,"href":"https:\/\/www.floridarehab.com\/wp-json\/wp\/v2\/staff\/289"},{"embeddable":true,"href":"https:\/\/www.floridarehab.com\/wp-json\/wp\/v2\/staff\/287"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.floridarehab.com\/wp-json\/wp\/v2\/media\/11578"}],"wp:attachment":[{"href":"https:\/\/www.floridarehab.com\/wp-json\/wp\/v2\/media?parent=2572"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.floridarehab.com\/wp-json\/wp\/v2\/categories?post=2572"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.floridarehab.com\/wp-json\/wp\/v2\/tags?post=2572"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}