{"id":3524,"date":"2023-07-27T07:18:26","date_gmt":"2023-07-27T07:18:26","guid":{"rendered":"https:\/\/www.floridarehab.com\/?page_id=3524"},"modified":"2025-02-07T12:31:25","modified_gmt":"2025-02-07T12:31:25","slug":"ketamine","status":"publish","type":"blog","link":"https:\/\/www.floridarehab.com\/drugs\/ketamine\/","title":{"rendered":"Ketamine: Uses, Dosage, Side Effects &#038; Potential for Abuse"},"content":{"rendered":"\n<p class=\"eplus-wrapper wp-block-paragraph\">Ketamine is a prescription drug that\u2019s also used for illegal recreational purposes. It has potentially dangerous effects, including addiction.<\/p>\n\n\n\n<p class=\"eplus-wrapper wp-block-paragraph\">Ketamine might be best known as a \u201cclub drug\u201d or as a \u201cdate rape drug.\u201d The drug is also commonly used as a horse tranquilizer. It actually began as a medical drug used for pain relief and anesthesia for humans and animals. Not only is it legal for use in medical settings, it may also be a&nbsp;<a href=\"https:\/\/www.therecoveryvillage.com\/mental-health\/depression\/news\/ketamine-for-depression\/\" target=\"_blank\" rel=\"noreferrer noopener\">promising treatment<\/a>&nbsp;for severe depression.<\/p>\n\n\n\n<p class=\"eplus-wrapper wp-block-paragraph\">Illicit ketamine use increased as it became known as a party drug in the 1980s. It produces feelings similar to&nbsp;<a href=\"https:\/\/www.floridarehab.com\/drugs\/pcp\/addiction\/\">phencyclidine (PCP)<\/a>&nbsp;that can be severe. People using ketamine describe the effects as a feeling of floating or being separated from their bodies. It can also produce hallucinations and sensory detachment.<\/p>\n\n\n\n<p class=\"eplus-wrapper wp-block-paragraph\">In addition to the high that ketamine use produces, it\u2019s also associated with numerous short- and long-term effects. Ketamine users are at risk of developing a tolerance to the drug. Ketamine misuse and addiction typically require professional help because of the seriousness of possible withdrawal symptoms.<\/p>\n\n\n\n<h2 class=\" wp-block-heading eplus-wrapper\">What Is Ketamine?<\/h2>\n\n\n\n<p class=\"eplus-wrapper wp-block-paragraph\">PCP was developed as an intravenous (IV) anesthetic in the 1950s. Because it produced severe side effects, researchers developed ketamine as a replacement. It\u2019s been approved for use as an anesthetic in the United States since the 1970s. Ketamine\u2019s drug class is a Schedule III drug, meaning it\u2019s approved for use in controlled medical settings.<\/p>\n\n\n\n<p class=\"eplus-wrapper wp-block-paragraph\">Schedule III drugs have a lower potential for abuse than drugs like&nbsp;<a href=\"https:\/\/www.floridarehab.com\/drugs\/heroin\/\">heroin<\/a>,&nbsp;<a href=\"https:\/\/www.floridarehab.com\/drugs\/meth\/addiction\/\">methamphetamine<\/a>, peyote, and&nbsp;<a href=\"https:\/\/www.floridarehab.com\/drugs\/cocaine\/addiction\/\">cocaine<\/a>, all of which are Schedule I or II drugs. There\u2019s still a risk of low physical or high psychological dependence. Other drugs in ketamine\u2019s drug schedule include anabolic steroids and medications with more than 90 mg of codeine per dose.<\/p>\n\n\n\n<p class=\"eplus-wrapper wp-block-paragraph\">Ketamine can be used for both humans and animals. Veterinary use may be part of the reason ketamine became known as a horse tranquilizer. It\u2019s also likely why the drug is sometimes called \u201ccat valium\u201d on the street.<\/p>\n\n\n\n<p class=\"eplus-wrapper wp-block-paragraph\">Beyond its legitimate medical uses, ketamine is a street drug that became popular with&nbsp;<a href=\"https:\/\/www.floridarehab.com\/resources\/teen-addiction\/\">teenagers<\/a>&nbsp;and&nbsp;<a href=\"https:\/\/www.floridarehab.com\/resources\/college-students\/\">young adults<\/a>. People misusing ketamine take it for the trance-like, floating feeling it can produce. It can also create extreme drowsiness at high doses. In addition, ketamine is one of the more common date rape drugs. Predators can slip the drug into people\u2019s drinks without the victims\u2019 knowing. It can cause loss of consciousness and anterograde amnesia, leaving the victim vulnerable to sexual assault and often unable to identify their assailant.<\/p>\n\n\n\n<h2 class=\" wp-block-heading eplus-wrapper\">Is Ketamine Legal?<\/h2>\n\n\n\n<p class=\"eplus-wrapper wp-block-paragraph\">Is ketamine legal? Yes, but only when prescribed by a doctor for its intended use in a controlled medical setting. In March 2019, the U.S. Food and Drug Administration (FDA) approved it&nbsp;<a href=\"https:\/\/www.fda.gov\/news-events\/press-announcements\/fda-approves-new-nasal-spray-medication-treatment-resistant-depression-available-only-certified\" target=\"_blank\" rel=\"noreferrer noopener\">to treat depression<\/a>&nbsp;in patients who have unsuccessfully tried other medications. This nasal spray has the potential to help patients who haven\u2019t found relief using standard treatments. Ketamine prescriptions are only available from certified doctors and clinics.<\/p>\n\n\n\n<p class=\"eplus-wrapper wp-block-paragraph\">Recreational ketamine use is illegal. Ketamine is considered a controlled substance. The U.S. Drug Enforcement Administration (DEA) notes that illegal ketamine distribution largely comes from Mexico. In addition to illegal ketamine that\u2019s smuggled over the border, the drugs that people misuse recreationally may come from international pharmaceutical organizations. The DEA was part of the effort to dismantle one such organization in 2005. The organization was smuggling illegal ketamine into the U.S. from India.<\/p>\n\n\n\n\n\n<h2 class=\" wp-block-heading eplus-wrapper\">What Is Ketamine Used For?<\/h2>\n\n\n\n<p class=\"eplus-wrapper wp-block-paragraph\">The World Health Organization (WHO) has included ketamine on its Essential Medicines list since 1985. Legitimate ketamine uses include anesthesia and pain relief in adults and children at low doses. The WHO also notes that it\u2019s among the&nbsp;<a href=\"https:\/\/docs.google.com\/viewer?url=https%3A%2F%2Fwww.who.int%2Fmedicines%2Fnews%2F20160309_FactFile_Ketamine.pdf\" target=\"_blank\" rel=\"noreferrer noopener\">safest anesthetics<\/a>&nbsp;and pain relievers because it doesn\u2019t slow breathing or lower blood pressure. This makes it suitable for global use in areas without reliable running water, oxygen and electricity.<\/p>\n\n\n\n<p class=\"eplus-wrapper wp-block-paragraph\">It also works with sedatives to reduce the need for stronger, more addictive painkillers like&nbsp;<a href=\"https:\/\/www.floridarehab.com\/drugs\/morphine\/\">morphine<\/a>. More rarely, doctors may also use <a href=\"https:\/\/www.floridarehab.com\/resources\/is-ketamine-an-opioid\/\">ketamine for pain<\/a> that\u2019s associated with conditions like:<\/p>\n\n\n\n<ul class=\" wp-block-list eplus-wrapper\">\n<li class=\" eplus-wrapper\">Fibromyalgia<\/li>\n\n\n\n<li class=\" eplus-wrapper\">Cancer<\/li>\n\n\n\n<li class=\" eplus-wrapper\">Neuropathy<\/li>\n\n\n\n<li class=\" eplus-wrapper\">Phantom pains<\/li>\n\n\n\n<li class=\" eplus-wrapper\">Sickle cell disease<\/li>\n\n\n\n<li class=\" eplus-wrapper\">Spinal injury<\/li>\n<\/ul>\n\n\n\n<p class=\"eplus-wrapper wp-block-paragraph\">The FDA has already approved ketamine as a treatment for depression, with the chief psychiatrist at Yale Medicine calling it a&nbsp;<a href=\"https:\/\/www.yalemedicine.org\/stories\/ketamine-depression\/\" target=\"_blank\" rel=\"noreferrer noopener\">\u201cgame-changer.\u201d<\/a>&nbsp;It works differently than other psychiatric medications to help&nbsp;<a href=\"https:\/\/www.yalemedicine.org\/stories\/ketamine-depression\/\" target=\"_blank\" rel=\"noreferrer noopener\">regrow connections<\/a>&nbsp;in your brain. This gives patients the opportunity to develop new positive behaviors and thoughts, without the rebound effects that other medications like&nbsp;<a href=\"https:\/\/www.floridarehab.com\/drugs\/valium\/addiction\/\">valium<\/a>&nbsp;might have.<\/p>\n\n\n\n<p class=\"eplus-wrapper wp-block-paragraph\">The depression treatment is a nasal spray called esketamine. Researchers found that&nbsp;<a href=\"https:\/\/www.yalemedicine.org\/stories\/ketamine-depression\/\" target=\"_blank\" rel=\"noreferrer noopener\">70% of depression patients<\/a>&nbsp;improved after taking an oral antidepressant and esketamine.<\/p>\n\n\n\n<p class=\"eplus-wrapper wp-block-paragraph\">Ketamine uses in veterinary medicine also include pain relief for animals. The drug is frequently used as an anesthetic because it acts quickly and doesn\u2019t depress breathing.<\/p>\n\n\n\n<h2 class=\" wp-block-heading eplus-wrapper\">Dosage and Administration<\/h2>\n\n\n\n<p class=\"eplus-wrapper wp-block-paragraph\">Ketamine is an effective anesthetic because it blocks a receptor in the brain to sedate the person and induce loss of consciousness. In addition to blocking key receptors in the brain, it also works on a molecular level to increase key chemicals like dopamine and noradrenaline.<\/p>\n\n\n\n<p class=\"eplus-wrapper wp-block-paragraph\">Ketamine doses vary depending on the patient, the purpose for using it and the way a doctor is administering the drug. For example, adult ketamine anesthesia&nbsp;<a href=\"https:\/\/reference.medscape.com\/drug\/ketalar-ketamine-343099\" target=\"_blank\" rel=\"noreferrer noopener\">doses<\/a>&nbsp;may start at anywhere from 1 mg to 4.5 mg per kg in an IV drip. If doctors are using other drugs together with ketamine, the dosage may be lower. If the doctor&nbsp;<a href=\"https:\/\/reference.medscape.com\/drug\/ketalar-ketamine-343099\" target=\"_blank\" rel=\"noreferrer noopener\">gives the drug<\/a>&nbsp;via intramuscular injection, the common dosage starts at 6.5 mg to 13 mg per kg. For children, the dosage is lower.<\/p>\n\n\n\n<p class=\"eplus-wrapper wp-block-paragraph\">When used for&nbsp;<a href=\"https:\/\/www.practicalpainmanagement.com\/patient\/treatments\/medications\/ketamine-chronic-pain-management-current-role-future-directions\" target=\"_blank\" rel=\"noreferrer noopener\">pain relief<\/a>, doctors may prescribe ketamine pills. More commonly, patients receive an IV ketamine drip given through a pump. Other methods include topical use and ketamine injections. Newer research into ketamine and depression has led to the ketamine nasal spray. This gives patients the freedom of outpatient treatment instead of having to go into the hospital or doctor\u2019s office for a ketamine drip or injection.<\/p>\n\n\n\n<p class=\"eplus-wrapper wp-block-paragraph\">There are several types of patients who are a good fit for ketamine treatment. These include patients with chronic pain who have not responded well to other types of pain treatments and chronic pain patients who are about to undergo surgery.<\/p>\n\n\n\n<p class=\"eplus-wrapper wp-block-paragraph\">Recreational ketamine users often snort, ingest or inject ketamine. Snorting is the most common method.&nbsp;<a href=\"https:\/\/www.deadiversion.usdoj.gov\/drug_chem_info\/ketamine.pdf\" target=\"_blank\" rel=\"noreferrer noopener\">The DEA notes<\/a>&nbsp;that the average dose for recreational users is about 100 mg. Those who use it orally may take higher doses.<\/p>\n\n\n\n<h2 class=\" wp-block-heading eplus-wrapper\">What Does Ketamine Look Like?<\/h2>\n\n\n\n<p class=\"eplus-wrapper wp-block-paragraph\">Ketamine pills, injections, IV infusions and recreational forms differ in their appearance. Liquid ketamine comes in glass vials. The liquid is clear.<\/p>\n\n\n\n<p class=\"eplus-wrapper wp-block-paragraph\">It\u2019s usually sold illegally as a pill or powder. White or off-white ketamine powder may come in capsules, plastic bags or little foil packs. The powder is colorless and odorless when dissolved in liquid.<\/p>\n\n\n\n<h2 class=\" wp-block-heading eplus-wrapper\">Street Names<\/h2>\n\n\n\n<p class=\"eplus-wrapper wp-block-paragraph\">The brand name for ketamine is Ketalar. Ketamine is the generic name for the same drug. Ketamine street names&nbsp;<a href=\"https:\/\/docs.google.com\/viewer?url=https%3A%2F%2Fwww.deadiversion.usdoj.gov%2Fdrug_chem_info%2Fketamine.pdf\" target=\"_blank\" rel=\"noreferrer noopener\">include<\/a>:<\/p>\n\n\n\n\n\n<h2 class=\" wp-block-heading eplus-wrapper\">Effects of Ketamine<\/h2>\n\n\n\n<p class=\"eplus-wrapper wp-block-paragraph\">Ketamine <a href=\"https:\/\/www.floridarehab.com\/resources\/drug-slang\/\">slang names<\/a> don\u2019t stop at nicknames for the drug \u2014 there are terms for the effects, too. One of the serious effects of ketamine on the body is called a \u201ck hole.\u201d This state is brought on by a high dose of the drug. Someone experiencing a k hole has taken a high enough dose to impair their bodily control and awareness of their surroundings. Someone in a k hole may be completely unable to move or their eyes may move slightly. Difficulties with speech and a profound feeling of disconnection are two other effects related to k holes.<\/p>\n\n\n\n<p class=\"eplus-wrapper wp-block-paragraph\">Ketamine effects aren\u2019t limited to k holes, either. Other common short-term ketamine effects include:<\/p>\n\n\n\n\n\n<p class=\"eplus-wrapper wp-block-paragraph\">Effects like loss of judgment and coordination can last for as long as 24 hours. Long-term effects include memory loss, stomach pain and bladder problems. Misusing ketamine puts you at a higher risk of unwanted effects such as:<\/p>\n\n\n\n\n\n<h2 class=\" wp-block-heading eplus-wrapper\">How Long Does Ketamine Stay in Your System?<\/h2>\n\n\n\n<p class=\"eplus-wrapper wp-block-paragraph\">Ketamine leaves most healthy adults\u2019 systems within 11 to 17 hours, but some of the metabolites created while your body processes the drug can last longer. Ketamine can be detected in urine for about 14 days and hair follicles for 90 days.<\/p>\n\n\n\n<p class=\"eplus-wrapper wp-block-paragraph\">Additionally, there are factors that affect how long ketamine stays in your system. These include:<\/p>\n\n\n\n\n\n<h2 class=\" wp-block-heading eplus-wrapper\">Is Ketamine Addictive?<\/h2>\n\n\n\n<p class=\"eplus-wrapper wp-block-paragraph\">Is ketamine physically or psychologically addictive? According to its drug classification, ketamine has a low risk for physical dependence and a high risk for psychological dependence. Long-term use increases the likelihood that someone will face an addiction. Using ketamine recreationally also increases the risk of developing a ketamine addiction.<\/p>\n\n\n\n<p class=\"eplus-wrapper wp-block-paragraph\">Prolonged use can increase your tolerance for ketamine. This means you might start taking more or take it more frequently to get the same effect. Having a dependence on ketamine can lead to withdrawal symptoms like:<\/p>\n\n\n\n\n\n<p class=\"eplus-wrapper wp-block-paragraph\">If you are living with a ketamine addiction, you don\u2019t have to face it alone. Treatment is just a phone call away at&nbsp;<a href=\"https:\/\/www.floridarehab.com\/contact-us\/\">The Recovery Village Palm Beach at Baptist Health<\/a>. Call today to discover the options available.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Ketamine is a prescription drug that\u2019s also used for illegal recreational purposes. It has potentially dangerous effects, including addiction. Ketamine might be best known as a \u201cclub drug\u201d or as a \u201cdate rape drug.\u201d The drug is also commonly used as a horse tranquilizer. It actually began as a medical drug used for pain relief [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":0,"parent":481,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false},"categories":[87],"tags":[],"class_list":["post-3524","blog","type-blog","status-publish","hentry","category-ketamine"],"acf":{"written_by":176,"enable_medically_and_up":["Yes"],"medically_reviewed_by":281,"medically_reviewed_content":"This article was reviewed by a medical professional to guarantee the delivery of accurate and up-to- date information. <a href=\"\/research\/\">View our research policy.<\/a>","up_to_date":"<i>Last Updated<\/i> - <b>12\/29\/2022<\/b>","page_first_published_date":"20221229","page_last_edit_date":"20221229","highlighted_description":"If you or a loved one is struggling with addiction, help is available. Speak with a Recovery Advocate by calling <a href=\"tel:8886480738\"><b>888-648-0738<\/b><\/a> now.","key_takeaways":"","source":{"source_label":"View Sources","source_content":"CESAR University of Maryland. \u201c<a href=\"http:\/\/www.cesar.umd.edu\/cesar\/drugs\/ketamine.asp\" target=\"_blank\" rel=\"noopener\">Ketamine<\/a>.\u201d Accessed October 21, 2019.\r\n\r\nU.S. Food and Drug Administration. \u201c<a href=\"https:\/\/www.fda.gov\/news-events\/press-announcements\/fda-approves-new-nasal-spray-medication-treatment-resistant-depression-available-only-certified\" target=\"_blank\" rel=\"noopener\">FDA Approves New Nasal Medication for Treatment-Resistant Depression; Available Only from a Certified Doctor\u2019s Office or Clinic<\/a>.\u201d March 5, 2019. Accessed October 21, 2019.\r\n\r\nDrug Enforcement Administration. \u201c<a href=\"https:\/\/docs.google.com\/viewer?url=https%3A%2F%2Fwww.deadiversion.usdoj.gov%2Fdrug_chem_info%2Fketamine.pdf\" target=\"_blank\" rel=\"noopener\">Ketamine<\/a>.\u201d August 2013. Accessed October 21, 2019.\r\n\r\nWorld Health Organization. \u201c<a href=\"https:\/\/docs.google.com\/viewer?url=https%3A%2F%2Fwww.who.int%2Fmedicines%2Fnews%2F20160309_FactFile_Ketamine.pdf\" target=\"_blank\" rel=\"noopener\">Fact File on Ketamine<\/a>.\u201d March 2016. Accessed October 20, 2019.\r\n\r\nChen, Jennifer. \u201c<a href=\"https:\/\/www.yalemedicine.org\/stories\/ketamine-depression\/\" target=\"_blank\" rel=\"noopener\">How New Ketamine Drug Helps with Depression<\/a>.\u201d Yale Medicine, March 21, 2019. Accessed October 21, 2019.\r\n\r\nMedscape. \u201c<a href=\"https:\/\/reference.medscape.com\/drug\/ketalar-ketamine-343099\" target=\"_blank\" rel=\"noopener\">Ketamine (Rx)<\/a>.\u201d Accessed 20 Oct. 2019.\r\n\r\nWadehra, Sunali; and von Gunten, Charles. \u201c<a href=\"https:\/\/www.practicalpainmanagement.com\/patient\/treatments\/medications\/ketamine-chronic-pain-management-current-role-future-directions\" target=\"_blank\" rel=\"noopener\">Ketamine for Chronic Pain Management: Current Role and Future Directions<\/a>.\u201d\u00a0 Practical Pain Management, December 4, 2018. Accessed October 21, 2019."},"staff_member_heading":"Authorship","staff_member":[{"staff_member_title":"Editor","select_staff_member":176},{"staff_member_title":"Medical Reviewer","select_staff_member":281}],"insurance_label":""},"_links":{"self":[{"href":"https:\/\/www.floridarehab.com\/wp-json\/wp\/v2\/blog\/3524","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.floridarehab.com\/wp-json\/wp\/v2\/blog"}],"about":[{"href":"https:\/\/www.floridarehab.com\/wp-json\/wp\/v2\/types\/blog"}],"author":[{"embeddable":true,"href":"https:\/\/www.floridarehab.com\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/www.floridarehab.com\/wp-json\/wp\/v2\/comments?post=3524"}],"version-history":[{"count":0,"href":"https:\/\/www.floridarehab.com\/wp-json\/wp\/v2\/blog\/3524\/revisions"}],"up":[{"embeddable":true,"href":"https:\/\/www.floridarehab.com\/wp-json\/wp\/v2\/blog\/481"}],"acf:post":[{"embeddable":true,"href":"https:\/\/www.floridarehab.com\/wp-json\/wp\/v2\/staff\/281"},{"embeddable":true,"href":"https:\/\/www.floridarehab.com\/wp-json\/wp\/v2\/staff\/176"}],"wp:attachment":[{"href":"https:\/\/www.floridarehab.com\/wp-json\/wp\/v2\/media?parent=3524"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.floridarehab.com\/wp-json\/wp\/v2\/categories?post=3524"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.floridarehab.com\/wp-json\/wp\/v2\/tags?post=3524"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}